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Paul, Minnesota, Usa robert callender, department of Biochemistry, albert einstein college of Medicine, Bronx, new york, Usa Britton chance, department of Biochemistry Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, Usa steven chu, lawrence Berkeley national laboratory, Berkeley, california, Usa louis J.
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] Target membrane VAMP Syntaxin SNAP-25 Transport vesicle Vesicle docking 1 Assembly of SNARE complexes SNARE complex Membrane fusion 3 NSF α-SNAP cis-SNARE complex Disassembly of SNARE complexes ATP ADP Pi 4 VAMP Rab GTP Syntaxin SNAP-25 Rab effector 2 Example 8-3.
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Blood wI Temp. Sterenborg, Lasers Med. Preneoplastic Lesions 51 CHAPTER 7 Facial Plastic and Reconstructive Surgery 375 WOUND HEALING Stages of Wound Healing Inflammatory (Substrate) Phase initialstage Hemostasis initialvasoconstrictionfor1015minutes(thromboxaneA2) followed by vasodilation (histamine, serotonin) endothelialcellscontractexposecollagen,fibronectin,and laminin forms platelet plug initiatescoagulation,kinin,andcomplementcycles Inflammatory (Cellular) Polymorphic Neutrophils (PMNs): appear within 6 hours, maximum cellular influx at 24 hours Macrophages: essential for wound healing (regulatory function), predominant cell type by day 3 and 4 Fibroblasts: appear by 48 hours, maximum cells at 15 days; predominant producer of collagen, elastin, and fibronectin (may differentiate into myofibroblasts which are important for wound contraction) Proliferative Phase 224days Re-epithelialization beginswithbasalepithelialcelldifferentiationandseparationfrom basement membrane (may be stimulated by epidermal growth factor) initialcellulardetachmentfromlossofdesmosomes,pseudopod formation migrationinleapfrogpatternwithfibronectinandothersat1221 μmhr (moist environment aids in migration) Neovascularization stimulatedbyhypoxia,acidity,andlactate Angiogenesis: migration of epithelial cells into perivascular spaces, forms channels and capillary buds Choosing and Preparing the Recipient Vessels 115 FIG.
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