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7 Structure of various gadolinium chelates: (a) Gd-DTPA, C. In an attempt to explain why immune responses require the recognition of two different determinants on the antigen and how the same antigen could both tolerize and immunize when given at different doses, they first suggested that antibody-forming cells must be tolerizable when stimulated through their antigen-specific receptor (this was referred to as signal one), but activated if they also received a second signal (referred to as signal two).

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The diagnosis of esophageal achalasia is confirmed by: (a) birds beak appearance on barium swallow (b) subatmospheric intraluminal esophageal pres- sure on manometry (c) endoscopic evidence of distal esophagitis (d) failure of lower esophageal sphincter relaxation on manometry (e) hyperperistalsis of the body of the esophagus 414.

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